pI: 6.7116 |
Length (AA): 195 |
MW (Da): 21444 |
Paralog Number:
28
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128183)
Species | Accession | Gene Product |
---|---|---|
Cryptosporidium parvum | cgd8_1040 | hypothetical protein |
Dictyostelium discoideum | DDB_G0292406 | Rab GTPase |
Drosophila melanogaster | Dmel_CG4921 | CG4921 gene product from transcript CG4921-RA |
Echinococcus granulosus | EgrG_001006600 | ras protein Rab 4A |
Echinococcus granulosus | EgrG_001004250 | ras protein RABF2b |
Echinococcus granulosus | EgrG_000995400 | ras GTP binding protein 4b |
Entamoeba histolytica | EHI_005010 | Rab family GTPase |
Echinococcus multilocularis | EmuJ_000995400 | ras GTP binding protein 4b |
Echinococcus multilocularis | EmuJ_001004250 | ras protein RABF2b |
Echinococcus multilocularis | EmuJ_001006600 | ras protein Rab 4A |
Homo sapiens | ENSG00000168118 | RAB4A, member RAS oncogene family |
Homo sapiens | ENSG00000167578 | RAB4B, member RAS oncogene family |
Leishmania braziliensis | LbrM.32.0600 | ras-related rab-4, putative |
Leishmania donovani | LdBPK_320520.1 | Ras-related protein Rab4, putative |
Leishmania infantum | LinJ.32.0520 | ras-related rab-4, putative |
Leishmania major | LmjF.32.0490 | ras-related rab-4, putative |
Leishmania mexicana | LmxM.31.0490 | ras-related rab-4, putative |
Mus musculus | ENSMUSG00000053291 | RAB4B, member RAS oncogene family |
Mus musculus | ENSMUSG00000019478 | RAB4A, member RAS oncogene family |
Neospora caninum | NCLIV_029730 | Ras family domain-containing protein, putative |
Schistosoma japonicum | Sjp_0064730 | ko:K07879 Ras-related protein Rab-4A, putative |
Schistosoma japonicum | Sjp_0037130 | Ras-related protein Rab-4A, putative |
Schistosoma mansoni | Smp_055670 | rab-2414 |
Schmidtea mediterranea | mk4.000832.01 | Putative rab-2,4,14 |
Schmidtea mediterranea | mk4.001989.00 | Putative rab-2,4,14 |
Schmidtea mediterranea | mk4.000674.05 | Putative rab-2,4,14 |
Trypanosoma brucei gambiense | Tbg972.11.15370 | ras-related rab-4, putative |
Trypanosoma brucei | Tb927.11.13750 | Ras-related protein Rab4 |
Trypanosoma congolense | TcIL3000.11.14140 | Ras-related protein Rab4, putative |
Trypanosoma cruzi | TcCLB.510911.30 | Ras-related protein Rab4, putative |
Toxoplasma gondii | TGME49_257340 | Ras family protein |
Trichomonas vaginalis | TVAG_474310 | rabb and C, putative |
Trichomonas vaginalis | TVAG_124590 | Rab6, putative |
Trichomonas vaginalis | TVAG_301200 | Rabx31 protein, putative |
Trichomonas vaginalis | TVAG_286490 | RAB, putative |
Trichomonas vaginalis | TVAG_051830 | RAC, putative |
Trichomonas vaginalis | TVAG_242000 | RAB, putative |
Trichomonas vaginalis | TVAG_073770 | Rabx6d protein, putative |
Trichomonas vaginalis | TVAG_132660 | Rab9, putative |
Trichomonas vaginalis | TVAG_350580 | Rab21, putative |
Trichomonas vaginalis | TVAG_446610 | small GTPase rabd, putative |
Trichomonas vaginalis | TVAG_038950 | Rabx3 protein, putative |
Trichomonas vaginalis | TVAG_207300 | Rab12, putative |
Trichomonas vaginalis | TVAG_006280 | RAB, putative |
Trichomonas vaginalis | TVAG_376820 | Rabx24 protein, putative |
Trichomonas vaginalis | TVAG_379730 | RAB, putative |
Trichomonas vaginalis | TVAG_331490 | Rabx18 protein, putative |
Trichomonas vaginalis | TVAG_122270 | RAB, putative |
Trichomonas vaginalis | TVAG_218200 | small GTPase rabh, putative |
Trichomonas vaginalis | TVAG_212320 | GTP-binding protein ypt11, putative |
Trichomonas vaginalis | TVAG_459760 | Rabx22 protein, putative |
Trichomonas vaginalis | TVAG_159810 | small GTPase RAB, putative |
Trichomonas vaginalis | TVAG_320200 | Rab5b, putative |
Trichomonas vaginalis | TVAG_337700 | Rab21, putative |
Trichomonas vaginalis | TVAG_205650 | Rab17, putative |
Trichomonas vaginalis | TVAG_570520 | Rab22, putative |
Trichomonas vaginalis | TVAG_031090 | RAB, putative |
Trichomonas vaginalis | TVAG_216900 | ras, putative |
Trichomonas vaginalis | TVAG_528800 | RAB-2,4 |
Trichomonas vaginalis | TVAG_180430 | RAB-36 and, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_257340 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.